Deadpool isn’t your average assassin. Sure, he has the skills, the swords, and the mutant healing factor—but what sets him apart is his flair for the absurd. In the world of comics, plenty of characters have racked up a high body count, but few do it with the chaotic creativity of Wade Wilson. Whether he’s decapitating icons or delivering a punchline mid-slaughter, Deadpool’s kills often defy logic, physics, and sometimes even continuity. And that’s exactly why fans love them. While other characters might use violence as a tool or a last resort, Deadpool uses it as performance art. His kills are theatrical, self-aware, and often disturbingly inventive. But don’t mistake the comedy for lack of impact—Deadpool’s deadliest moments have shaken timelines, rewritten universes, and occasionally left even the most seasoned Marvel characters speechless. In this list, we’re slicing into the ten most ridiculous, over-the-top kills Deadpool has ever committed in the comics. These moments are bloody, bizarre, and unforgettable—just like the Merc with a Mouth himself.
#10: Killing the Marvel Universe (Literally) – Deadpool Kills the Marvel Universe
In one of the most infamous storylines of all time, Deadpool Kills the Marvel Universe, Wade Wilson snaps. After being “cured” by a team of twisted doctors who make him fully aware he’s a comic book character, Deadpool goes on a full-blown meta murder spree. He doesn’t just take down a few heroes—he annihilates everyone. From Spider-Man to the Avengers, from the X-Men to cosmic beings, Deadpool systematically slaughters the entire Marvel cast.
What makes this so over-the-top isn’t just the sheer scope—it’s the twisted creativity behind each kill. He outsmarts Reed Richards, slices Thor, and even eliminates the Watcher. Then, in one of the most fourth-wall-shattering finales ever, Deadpool walks into the Marvel writers’ room and prepares to kill them, too. It’s not just a kill spree—it’s a comic book apocalypse engineered by a madman with a sense of humor. No one is safe, no one is sacred, and it’s pure, unfiltered Deadpool.
#9: Turning the Hulk Into Ground Meat – Deadpool Kills the Marvel Universe Again
In the sequel, Deadpool continues his universe-wiping path, and he doesn’t shy away from tough targets. One of his most jaw-dropping kills? The Hulk. That’s right—Wade Wilson takes on Bruce Banner, and somehow manages to take him out. The plan? Wait until Banner turns back into his human form. Deadpool ambushes him, wakes him up just enough to say something snarky, and then boom—a bullet to the brain.
It’s not the most respectful way to kill someone, but Deadpool isn’t exactly big on honor. This moment is over-the-top because it proves that even Marvel’s strongest rage monster is no match for Wade’s cunning—and his complete disregard for moral boundaries. Also, the follow-up panel showing Hulk’s shredded remains is disturbingly graphic, even by Deadpool standards. It’s brutal, efficient, and yet still somehow funny.
#8: Beheading a Vampire with a Chimichanga – Deadpool: Dracula’s Gauntlet
Leave it to Deadpool to weaponize a snack. In Dracula’s Gauntlet, a hilariously absurd miniseries that sees Deadpool delivering a vampire bride, Wade gets attacked by a group of bloodsuckers. One vampire lunges at him—and Deadpool defends himself with a flaming chimichanga. Yes, a chimichanga. One fiery toss later, and the vampire’s head is rolling.
It’s classic Deadpool: ridiculous, culinary-based violence that still ends in a clean kill. And while most vampire hunters rely on stakes or sunlight, Wade proves once again that there’s no problem that can’t be solved with a greasy snack and a complete lack of impulse control. The panel where he holds up the charred tortilla and says, “Medium rare… just like your future,” is peak Deadpool energy.
#7: Taking Out Thanos With a Single Thought – Deadpool vs. Thanos
Deadpool and Thanos have a complicated relationship, mostly revolving around their shared love interest: Lady Death. In Deadpool vs. Thanos, the two rivals fight in increasingly ridiculous ways, but one moment takes the taco: Deadpool defeats Thanos by turning his own immortality against him.
After stealing a cosmic artifact that allows him to manipulate life and death, Deadpool uses it to trap Thanos in an endless loop of nonexistence—effectively out-deathing the Mad Titan. While most heroes need armies or gauntlets to face Thanos, Deadpool uses a cheat code only he would find. It’s nonsensical, hilarious, and exactly what you’d expect from the guy who once wore a rubber chicken as armor.
#6: Slicing the X-Men to Ribbons – Deadpool Kills the Marvel Universe (Again)
In yet another bloody encounter, Deadpool faces off with the X-Men—but instead of being overwhelmed, he butchers them with disturbing ease. Cyclops? Vaporized. Beast? Dismembered. Wolverine? Taken out in a surprisingly efficient ambush. The whole sequence reads like a slasher flick directed by someone with ADHD and a grudge against Charles Xavier.
Deadpool doesn’t just kill them—he taunts them, toys with them, and makes it entertaining for himself. It’s excessive, gory, and impossible to ignore. Even fans of the X-Men can’t help but be impressed (and mildly horrified) by how over-the-top and surgical his massacre becomes. It’s Deadpool unchained—and the carnage is unforgettable.
#5: Blowing Up the Fourth Wall—Literally – Deadpool Kills Deadpool
You know things are getting unhinged when Deadpool starts killing himself. In Deadpool Kills Deadpool, the Merc with a Mouth jumps through dimensions to wipe out every version of himself—yes, including Pirate Deadpool, Panda Deadpool, and even Headpool (the zombie head version). Why? Because he’s on a mission to destroy the multiverse’s Deadpool infection, driven by a version of himself that has fully embraced nihilistic genocide.
The over-the-top part isn’t just the number of kills—it’s the sheer creativity. He dismembers, explodes, poisons, and slices through alternate Deadpools like he’s checking off a to-do list. It’s gory, funny, and a complete meta spiral. One standout moment is when he turns the page sideways in a comic book and drops an anvil on an enemy—channeling full Looney Tunes chaos in the middle of a multiversal bloodbath. Deadpool doesn’t just bend the rules of logic here—he shatters them with a sledgehammer, proving once again that the only thing he respects is absurdity itself.
#4: Weaponizing Literature – Deadpool Killustrated
Ever wonder what it would look like if Deadpool went after the characters that inspired the Marvel Universe? In Deadpool Killustrated, Wade decides to strike at the roots of heroism by diving into classic literature and murdering legendary fictional icons. Yes, it’s exactly as ridiculous—and brilliant—as it sounds. He stabs Moby Dick with a harpoon, burns the Jungle Book animals alive, and kills Sherlock Holmes with cold efficiency.
The highlight? Watching him outwit the literary greats using meta-knowledge. He doesn’t just fight them—he deconstructs them, mocking narrative structure while setting fire to classic storytelling. He travels through a surreal, stylized version of books and turns Victorian landscapes into crimson horror shows. The sheer concept of killing literary icons as a way to destabilize the superhero genre is a level of over-the-top meta that only Deadpool could pull off. And somehow, he makes it both terrifying and hilarious.
#3: Cutting Galactus Down to Size – Deadpool #45 (aka Deadpool #250)
Deadpool killing Galactus sounds impossible—but that’s exactly what makes it so ridiculous. In Deadpool #45 (the 250th issue in legacy numbering), there’s a special story set in a far-off future where Deadpool takes on a shrunken version of the World-Eater. It’s a parody, sure, but the visual of Wade drop-kicking a pint-sized Galactus into the sun is so absurd, it became instantly iconic.
The sequence includes Wade gearing up with cosmic gadgets, making fun of editorial decisions, and then just punting Galactus like a football. This kill is less about gore and more about scale—pun intended. It’s a complete breakdown of cosmic hierarchy, where a character known for fart jokes manages to one-up a force of nature. Deadpool doesn’t just defeat Galactus—he roasts him, literally and metaphorically, and proves that comedy might just be the strongest weapon in the Marvel Universe.
#2: Using Loki’s Head as a Weapon – Deadpool #37 (Vol. 2)
Loki, the God of Mischief, once tried to curse Deadpool with immortality (and in some stories, even claims to be his father). Their relationship is predictably messy, but in Deadpool #37, Wade gets the upper hand in the most Deadpool way possible—by literally decapitating Loki and swinging his head around like a flail. And yes, Loki’s still alive, trash-talking the entire time.
This moment is outrageously brutal and comedically perfect. The idea of Deadpool wielding the still-talking, eye-rolling head of a Norse god to bludgeon enemies is the kind of visual gag that feels ripped from a mythological fever dream. And in the middle of the carnage, Wade pauses to argue with Loki’s head about parenting issues and destiny. The scene is equal parts fight choreography and stand-up routine, cementing it as one of the most bizarre kills ever committed to comic panels.
#1: Nuking the Entire Comic Book Medium – Deadpool Kills the Marvel Universe (The End)
In the culmination of his murder spree across the multiverse, Deadpool doesn’t just kill characters—he targets the entire idea of comics themselves. In Deadpool Kills the Marvel Universe (The End), Wade becomes aware that even when he kills everyone, the stories just reset. So what does he do? He blows up the foundation of comic storytelling altogether.
He hunts down the Narrator. He destroys the script. He confronts the reader’s perspective itself. He enters a blank comic book panel and erases everything, muttering, “If I can’t win… I’ll just end the game.” The final panels are a stark white void, with nothing left but the absence of fiction. It’s the ultimate over-the-top Deadpool kill—not of a person, not of a hero, but of existence within comics. Only Deadpool could turn nihilism into a punchline and make the annihilation of narrative itself feel like the grand finale of a stand-up special gone homicidally rogue.
Deadpool doesn’t just kill—he kills with style. His most over-the-top kills aren’t about shock value alone; they’re meta, satirical, and uniquely Wade Wilson. Whether he’s slicing through timelines, parodying literary classics, or dismembering gods while cracking jokes, every kill is a reminder that Deadpool is both a master assassin and a comic book force of nature. He doesn’t just break the fourth wall—he detonates it. And in doing so, he redefines what it means to be a killer in the Marvel Universe… one twisted laugh at a time.
