Family Guy is no stranger to mayhem, and over the years, it has given us a wild variety of villains—some truly despicable, others hilariously petty. But in classic Seth MacFarlane fashion, even the evillest characters are served with a side of absurdity. These antagonists range from diabolical babies to twisted businessmen, but every one of them has delivered unforgettable laughs alongside their villainy. Whether they’re trying to destroy Quahog or just ruin Peter’s Day, they’re always up to no good—and we can’t get enough. Here are the Top 10 most evil Family Guy villains who somehow left us laughing in the process.
#10: Ernie the Giant Chicken
Ernie isn’t your typical villain with a master plan—he’s a giant chicken with a personal vendetta and an affinity for over-the-top, city-destroying fistfights. His endless, explosive battles with Peter Griffin are both ridiculously destructive and hilariously drawn out, often going on for minutes in a single episode. What makes Ernie so evil is how relentless and inconvenient he is. He’ll show up out of nowhere—at weddings, on airplanes, even in the middle of Peter’s relaxing bath—just to settle a grudge we never fully understand. Their rivalry defies logic, space, and time, and that’s part of the joke. Ernie doesn’t speak. He doesn’t scheme. He just punches—and punches hard. And despite the wreckage, we laugh every time. His chaos is cartooning gold: equal parts Looney Tunes and Die Hard. He may not be evil in the traditional sense, but when your life goal is to wreck Peter’s existence in slow motion, you’ve earned your spot on the list.
#9: Bertram
Stewie’s half-brother and intellectual equal, Bertram is the kind of villain who threatens global annihilation—but does it with a British accent and impeccable comedic timing. Voiced by Wallace Shawn, Bertram appears multiple times throughout the series, each time concocting increasingly ridiculous plans to destroy Stewie—or the world. In one episode, he builds a time machine to eliminate Stewie by assassinating Leonardo da Vinci. Another time, he creates a genetically engineered army. Bertram is clever, ruthless, and weirdly charming—like a Bond villain if he went to prep school and never learned how to emotionally regulate. What makes Bertram so entertaining is that his battles with Stewie are less about good vs. evil and more about ego vs. ego. They’re both brilliant, evil toddlers trying to outpetty each other, and that dynamic makes for some of the most memorable episodes in Family Guy history. Bertram might be the antagonist, but we’re often rooting for both of them.
#8: Angela
Angela, Peter’s boss at the brewery (voiced by the late, great Carrie Fisher), may not seem evil at first glance—but under her passive-aggressive exterior lies a tyrant in a blazer. She’s sarcastic, cold, and completely unafraid to humiliate Peter at every opportunity. Whether it’s assigning him the worst tasks, criticizing his every move, or just making him squirm for fun, Angela rules the Pawtucket Brewery like it’s a dictatorship—and Peter is her favorite punching bag. What makes her villainy so funny is how casually cruel she is. She doesn’t raise her voice or get physical. She just cuts Peter down with deadpan lines and bureaucratic nonsense. Her humor is dry, her power is unchecked, and her disdain for Peter is oddly relatable. Angela isn’t out to conquer the world—she just wants to survive the workday while making Peter’s life a little more miserable. And we love her for it.
#7: Lois Griffin (When She Snaps)
Yes, Lois is usually the moral compass of the Griffin household—but when she snaps, she goes full villain in the most entertaining way. Whether it’s her dark past as a kleptomaniac, her obsession with piano competition rival Gretchen Mercer, or that time she became a ruthless MMA fighter, Lois has a mean streak that rivals any villain. The most unforgettable moment? When she becomes Stewie’s nemesis in the epic “Lois Kills Stewie” arc. With sniper rifles, hand-to-hand combat, and full-blown action movie energy, Lois takes on Stewie like she’s in Mission: Impossible. Her transition from sweet mom to cold-blooded killer is both terrifying and hilarious. Lois’s villainous side shows us that underneath her composed suburban exterior is a woman one step away from unleashing absolute chaos. And when she does? We can’t look away.
#6: Stewie Griffin
Let’s be honest—Stewie was the villain of the show when it began. The megalomaniacal infant obsessed with world domination and matricide delivered some of the show’s most iconic early moments. “Victory is mine!” was his war cry, and he meant it. From building death rays to traveling through time to kill his future self, Stewie has done eviler before age two than most villains do in a lifetime. But here’s the twist—he’s also incredibly lovable. His wit, flamboyance, and ever-changing British accent make his evil deeds feel more like eccentric hobbies than actual threats. Over time, Stewie’s character evolved, but his villainy remains part of his DNA. Whether he’s blowing up a preschool or launching a rocket into space just to outdo Brian, he’s always walking the line between adorable and diabolical. And that’s why we laugh. He’s the only baby who could threaten global genocide and still make you want to hug him.
#5: Carter Pewterschmidt
Lois’s wealthy father, Carter Pewterschmidt, is the very definition of a cartoon capitalist villain. He’s rich, rude, and absolutely rotten to his core. Whether he’s trying to destroy local businesses, cheating on his taxes, or publicly humiliating Peter for fun, Carter does it all with the smugness of a man who thinks the poor are allergic to bootstraps. He doesn’t just dislike Peter—he actively tries to sabotage his life at every opportunity, often using his vast resources to crush Peter’s dreams. What makes Carter’s villainy so hilarious is how casually monstrous he is. He once tried to buy Peter’s kidney. Another time, he staged his own death to avoid giving away his fortune. His one-liners are dripping with elitist disdain, and his total lack of self-awareness makes him cartoon evil at its finest. He’s like Mr. Burns with a yacht and a country club membership—and every time he shows up, you know something dark (and hilarious) is about to happen.
#4: Death (The Grim Reaper)
Death in Family Guy is somehow both terrifying and a total bro. Voiced hilariously by Norm Macdonald in his first appearance and later by Adam Carolla, Death shows up with a skeletal grin and dry sarcasm every time someone’s about to kick the bucket—or needs a lesson in mortality. One of his most iconic moments is when he sprains his ankle chasing Peter and has to crash at the Griffins’ house, revealing he’s just a tired employee in a soul-reaping grind. His deadpan humor, complaints about work, and awkward social presence make him one of the show’s most memorable villains. Sure, he’s the embodiment of death—but he’s also the guy who’ll eat pizza on your couch while waiting to collect your soul. His moments aren’t just funny—they flip our expectations of the grim reaper trope, making Death one of the funniest evil forces the show has ever created.
#3: Mayor Adam West
He may not have been intentionally evil, but Mayor Adam West’s bizarre, delusional leadership often turned him into a chaotic force of destruction. Whether it was spending the city budget on digging a massive, pointless hole or declaring martial law over a cat outbreak, West made Quahog more dangerous every time he opened his mouth. Voiced by the legendary Adam West himself, the character was a masterclass in absurd villainy. He wasn’t malicious—just completely insane. And that made him even more dangerous. His decision-making led to disasters, panic, and economic ruin, but his deadpan delivery made it comedy gold. He was the kind of villain you couldn’t hate because you were too busy laughing at how completely detached from reality he was. His legacy on the show is a tribute to madness done right—and every scene he was in felt like you were watching a train wreck narrated by a game show host.
#2: James Woods
Real-life actor James Woods became a fictional Family Guy villain in a way no one saw coming. The show turned him into a self-absorbed, sociopathic chaos agent who repeatedly returned from the dead (or faked his death) to torment Peter and the gang. From stealing Peter’s identity to rigging an election, James Woods played a heightened version of himself that was both hilariously evil and relentlessly annoying. He’s that rare kind of villain who never overstays his welcome because he’s always upping the ante. He doesn’t want money. He doesn’t want power. He wants attention—and he’ll blow up your life to get it. Woods’ ability to switch between faux-sincerity and villainous laughter made him a fan-favorite antagonist. His episodes are part sitcom, part psychological horror, and all meta-commentary on celebrity ego. And that’s why we can’t stop watching—even as we cringe.
#1: Stewie Griffin (Again) – At His Absolute Worst
Stewie deserves a second spot—and this time, we’re talking about peak evil Stewie. In episodes like “The Tan Aquatic with Steve Zissou” and the “Road to” specials, Stewie dabbles in casual villainy. But in the iconic two-parter “Stewie Kills Lois” and “Lois Kills Stewie,” we see him fully unhinged. He shoots his mother in cold blood, seizes global power, and becomes a full-blown dystopian dictator—all with theatrical flair and Broadway-level musical numbers. This isn’t cute, conflicted Stewie. This is Dr. Doom in Pampers. He becomes a global tyrant, executes his enemies, and nearly takes over the world before Lois comes back for revenge. It’s a wild ride packed with violence, betrayal, and unforgettable one-liners—like when Stewie announces, “Victory shall be mine!” moments before vaporizing someone. It’s pure, unfiltered evil—but so funny and over-the-top that it becomes Family Guy legend. No other villain on the show has matched the scale of Stewie’s worst moments, and no one ever will.
Family Guy villains aren’t just evil—they’re hilarious, exaggerated caricatures who bring chaos and comedy in equal measure. Whether it’s Stewie plotting world domination or James Woods gaslighting an entire town, each of these characters manages to leave a lasting impression while making us laugh at the madness. In true Family Guy fashion, their villainy is always wrapped in absurdity, satire, and just enough heart to keep us coming back. These villains don’t just wreck Quahog—they elevate it.
